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Long term use of Anavar is associated with decreased and flabby muscle mass, loss of libido and excessive weight gain, as well as muscle-wasting illnesses, muscle pain and degeneration. The high cost and complexity involved in anavar therapy have deterred many clinicians from accepting treatment. But now that we can deliver Anavar on a long term basis, and with very good results, many clinicians are rethinking the need for continued treatment or using treatments based on newer approaches such as caloric restriction. The benefits of caloric restriction (CR) in the treatment of muscle wasting diseases such as sarcopenia (fatigued muscle) have recently been supported by clinical trial results from Japan (8). A recent study (9) reported that long term CR increased muscle power in healthy older men, as measured by a test that required resistance exercise (8). The same study reported that the reduction in blood pressure (BP) with long term CR (≥60% of HRmax) in older men, was similar to those with CR in younger men (the effects of older age and BMI on HRmax were not determined.).
A number of randomized controlled trials (8,17) have shown that subjects taking CR, reduced body weight and increased muscle glycogen at rest, followed by increasing carbohydrates and increasing fat, lose the most muscle mass and lean mass (in fact, CR appears to increase muscle cell protein synthesis in skeletal muscle in elderly compared with young men (8)). These results have led many clinicians to advocate CR in healthy older men as one of the best ways to preserve muscle mass and lean body mass. Unfortunately, these results did not take into account the very long term effects of a low calorie diet (≈1.5 L/day) in older men. We now know that the high-carbohydrate, low-fat diet, which has been associated with weight loss, loss of lean mass and preservation of muscle mass in the elderly, reduces energy requirements by 50%, and that the reduction in caloric and protein intake (as a result of calorie restriction) reduces muscle mass and lean mass. The long term effects of CR and a low calorie diet and the long term effects of the low-fat diet on muscle mass and muscle function are now being investigated in many different diseases.
We have known for some time that there are beneficial effects of low sodium (3.4-1.6 mEq/L) diets (18) and of reducing carbohydrates by 50% (20), but our new knowledge of that diet, which is very low in fat and in salt, which is what Anavar is, is helping us to
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